Season 4

4 gen 2010 · 30 min

We're starting off the new year with Robin Thicke and his Sex Therapy...like father like son. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Guy Branum are on the panel.

5 gen 2010 · 30 min

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

6 gen 2010 · 30 min

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

7 gen 2010 · 30 min

Holly Madison is dropping on by her old E! family today...we've missed her, too. Comedian Donnel Rawlings, comedian Heather McDonald and comedian Gary Valentine.

11 gen 2010 · 30 min

Word on the street is Giuliana and Bill Rancic are trying to have a baby. What're the odds that we'll get any sort of big announcement? Comedian Brad Wollack, comedian Natasha Leggero and comedian Matt Braunger.

12 gen 2010 · 30 min

We welcome back the very funny Aisha Tyler, from the new show Archer. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

13 gen 2010 · 30 min

Amy Brenneman of Private Practice stops by, perhaps with some doctorly advice. Comedian John Caparulo, comedian Jen Kirkman and comedian Dan Levy.

14 gen 2010 · 30 min

Fist pumps all around for Jersey Shore's Snooki, Pauly D and The Situation. Comedian Chris Franjola, comedian Whitney Cummings and TV personality Ross Mathews.

18 gen 2010 · 30 min

David Arquette is back and telling us all about his new play The Female of the Species and the Golden Globes! Comedians Michelle Collins and Randy and Jason Sklar

19 gen 2010 · 30 min

Clear eyes, full hearts, can't lose with Legion's Adrianne Palicki (aka FNL's Tyra). Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Eric Price.

20 gen 2010 · 30 min

Who wouldn't be stoked that Kaley Cuoco from the megapopular Big Bang Theory is here? Comedian Heather McDonald, TV personality Ross Mathews and comedian Lavell Crawford.

21 gen 2010 · 30 min

James Van Der Beek is in the new movie Formosa Betrayed and popping up all over TV—even here! E!'s own Michael Yo, comedian Sarah Colonna and comedian Guy Branum.

25 gen 2010 · 30 min

26 gen 2010 · 30 min

27 gen 2010 · 30 min

28 gen 2010 · 30 min

1 feb 2010 · 30 min

2 feb 2010 · 30 min

3 feb 2010 · 30 min

4 feb 2010 · 30 min

8 feb 2010 · 30 min

9 feb 2010 · 30 min

10 feb 2010 · 30 min

We're beyond pleased to welcome back our animal guy Dave Salmoni and his new animal friends. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Mo Mandel.

12 feb 2010 · 30 min

15 feb 2010 · 30 min

We get down to business with The Office's Kate Flannery. Comedian Loni Love, comedian Dan Levy and comedian Whitney Cummings.

16 feb 2010 · 30 min

Things get really scandalous when author Jackie Collins stops by with her new book, Poor Little Bitch Girl. Comedian Chris Hardwick, comedian Jen Kirkman and comedian Jo Koy.

17 feb 2010 · 30 min

Lisa Edelstein from House is back again...Wait, so who's running Princeton Plainsboro? Comedian Josh Wolf, comedian Heather McDonald and comedian Ryan Stout.

18 feb 2010 · 30 min

22 feb 2010 · 30 min

House of Payne's Keshia Knight Pulliam is one hard working lady; Dr. Huxtable would be so proud. Comedian Loni Love, TV personality Rove McManus and comedian Michelle Collins

23 feb 2010 · 30 min

We're pretty thrilled that Danica Patrick makes a pit stop over at Chelsea Lately today. Comedian Josh Wolf, comedian Whitney Cummings and comedian Jo Koy.

24 feb 2010 · 30 min

Things might get wild with Radha Mitchell star of the new thrilling horror movie The Crazies. Comedian John Caparulo, comedian Bill Bellamy and actress-comedian Arden Myrin.

25 feb 2010 · 30 min

The Chelsea Lately cast do a Kardashian skit. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

1 mar 2010 · 30 min

From the new movie Cop Out we've got Seann William Scott in our custody today. Comedian Chris Hardwick and Comedians Randy and Jason Sklar.

2 mar 2010 · 30 min

Kendra and Hank Baskett are here to tell us all about the spellbinding new season of Kendra. E!'s own Michael Yo, comedian Sarah Colonna and comedian Jo Koy.

3 mar 2010 · 30 min

Please enjoy a very special Handler Edition of Single Staffers. Comedian Matt Bruanger, comedian Heather McDonald and comedian Moshe Kasher.

4 mar 2010 · 30 min

From Precious, the Academy Award-nominated Gabourey Sidibe is here. TV personality Ross Mathews, comedian Christina Pazsitzky and comedian Guy Branum.

8 mar 2010 · 30 min

Someone got some time away from the O.R., Grey's Anatomy's Kevin McKidd is here. Comedian John Caparulo, comedian Arden Myrin and comedian Chris Franjola.

9 mar 2010 · 30 min

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

10 mar 2010 · 30 min

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

11 mar 2010 · 30 min

Alexis Neiers, Gabrielle Neiers and Tess Taylor are here from their aptly titled new series on E! Pretty Wild. Comedian Brad Wollack, comedian Dan Levy and comedian Josh Wolf.

15 mar 2010 · 30 min

90210's Shenae Grimes is here to give us the deets on all things West Beverly. Comedian Bobby Lee, comedian T.J. Miller and comedian Whitney Cummings.

16 mar 2010 · 30 min

From the highly anticipated Diary of a Wimpy Kid, the purely entertaining Rachael Harris is here. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

17 mar 2010 · 30 min

We catch up with Avril Lavigne, who sings "Alice," the title song from Tim Burton's Alice in Wonderland. Comedian Sarah Colonna, comedian/TV host Rove McManus and comedian Mo Mandel.

18 mar 2010 · 30 min

We're so thrilled to welcome the author of Where Mercy Is Shown, Mercy Is Given, Dog the Bounty Hunter. Comedian John Caparulo, comedian Heather McDonald and TV personality Ross Mathews.

22 mar 2010 · 30 min

23 mar 2010 · 30 min

24 mar 2010 · 30 min

25 mar 2010 · 30 min

29 mar 2010 · 30 min

Ludacris is back with his new album Battle of the Sexes and this time he's bringing drinks. Comedian Ben Gleib, comedian Natasha Leggero and comedian Guy Branum.

30 mar 2010 · 30 min

Johnny Weir is here, and unfortunately our show is not "on ice" this week. Comedian Jo Koy, comedian Lil JJ and comedian Sarah Colonna.