Season 4

04.01.2010 · 30 Min.

We're starting off the new year with Robin Thicke and his Sex Therapy...like father like son. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Guy Branum are on the panel.

05.01.2010 · 30 Min.

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

06.01.2010 · 30 Min.

We're getting deep with Mary J. Blige and her new album, Stronger With Each Tear, word. Comedian Chris Hardwick, comedians Randy and Jason Sklar.

07.01.2010 · 30 Min.

Holly Madison is dropping on by her old E! family today...we've missed her, too. Comedian Donnel Rawlings, comedian Heather McDonald and comedian Gary Valentine.

11.01.2010 · 30 Min.

Word on the street is Giuliana and Bill Rancic are trying to have a baby. What're the odds that we'll get any sort of big announcement? Comedian Brad Wollack, comedian Natasha Leggero and comedian Matt Braunger.

12.01.2010 · 30 Min.

We welcome back the very funny Aisha Tyler, from the new show Archer. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

13.01.2010 · 30 Min.

Amy Brenneman of Private Practice stops by, perhaps with some doctorly advice. Comedian John Caparulo, comedian Jen Kirkman and comedian Dan Levy.

14.01.2010 · 30 Min.

Fist pumps all around for Jersey Shore's Snooki, Pauly D and The Situation. Comedian Chris Franjola, comedian Whitney Cummings and TV personality Ross Mathews.

18.01.2010 · 30 Min.

David Arquette is back and telling us all about his new play The Female of the Species and the Golden Globes! Comedians Michelle Collins and Randy and Jason Sklar

19.01.2010 · 30 Min.

Clear eyes, full hearts, can't lose with Legion's Adrianne Palicki (aka FNL's Tyra). Comedian Chris Hardwick, actress-comedian Arden Myrin and comedian Eric Price.

20.01.2010 · 30 Min.

Who wouldn't be stoked that Kaley Cuoco from the megapopular Big Bang Theory is here? Comedian Heather McDonald, TV personality Ross Mathews and comedian Lavell Crawford.

21.01.2010 · 30 Min.

James Van Der Beek is in the new movie Formosa Betrayed and popping up all over TV—even here! E!'s own Michael Yo, comedian Sarah Colonna and comedian Guy Branum.

25.01.2010 · 30 Min.

26.01.2010 · 30 Min.

27.01.2010 · 30 Min.

28.01.2010 · 30 Min.

01.02.2010 · 30 Min.

02.02.2010 · 30 Min.

03.02.2010 · 30 Min.

04.02.2010 · 30 Min.

08.02.2010 · 30 Min.

09.02.2010 · 30 Min.

10.02.2010 · 30 Min.

We're beyond pleased to welcome back our animal guy Dave Salmoni and his new animal friends. Comedian Jo Koy, comedian Christina Pazsitzky and comedian Mo Mandel.

12.02.2010 · 30 Min.

15.02.2010 · 30 Min.

We get down to business with The Office's Kate Flannery. Comedian Loni Love, comedian Dan Levy and comedian Whitney Cummings.

16.02.2010 · 30 Min.

Things get really scandalous when author Jackie Collins stops by with her new book, Poor Little Bitch Girl. Comedian Chris Hardwick, comedian Jen Kirkman and comedian Jo Koy.

17.02.2010 · 30 Min.

Lisa Edelstein from House is back again...Wait, so who's running Princeton Plainsboro? Comedian Josh Wolf, comedian Heather McDonald and comedian Ryan Stout.

18.02.2010 · 30 Min.

22.02.2010 · 30 Min.

House of Payne's Keshia Knight Pulliam is one hard working lady; Dr. Huxtable would be so proud. Comedian Loni Love, TV personality Rove McManus and comedian Michelle Collins

23.02.2010 · 30 Min.

We're pretty thrilled that Danica Patrick makes a pit stop over at Chelsea Lately today. Comedian Josh Wolf, comedian Whitney Cummings and comedian Jo Koy.

24.02.2010 · 30 Min.

Things might get wild with Radha Mitchell star of the new thrilling horror movie The Crazies. Comedian John Caparulo, comedian Bill Bellamy and actress-comedian Arden Myrin.

25.02.2010 · 30 Min.

The Chelsea Lately cast do a Kardashian skit. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

01.03.2010 · 30 Min.

From the new movie Cop Out we've got Seann William Scott in our custody today. Comedian Chris Hardwick and Comedians Randy and Jason Sklar.

02.03.2010 · 30 Min.

Kendra and Hank Baskett are here to tell us all about the spellbinding new season of Kendra. E!'s own Michael Yo, comedian Sarah Colonna and comedian Jo Koy.

03.03.2010 · 30 Min.

Please enjoy a very special Handler Edition of Single Staffers. Comedian Matt Bruanger, comedian Heather McDonald and comedian Moshe Kasher.

04.03.2010 · 30 Min.

From Precious, the Academy Award-nominated Gabourey Sidibe is here. TV personality Ross Mathews, comedian Christina Pazsitzky and comedian Guy Branum.

08.03.2010 · 30 Min.

Someone got some time away from the O.R., Grey's Anatomy's Kevin McKidd is here. Comedian John Caparulo, comedian Arden Myrin and comedian Chris Franjola.

09.03.2010 · 30 Min.

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

10.03.2010 · 30 Min.

Chelsea Chelsea Bang Bang is in stores now...You're welcome, everyone. Comedian Brad Wollack, comedian Natasha Leggero and comedian Ben Gleib.

11.03.2010 · 30 Min.

Alexis Neiers, Gabrielle Neiers and Tess Taylor are here from their aptly titled new series on E! Pretty Wild. Comedian Brad Wollack, comedian Dan Levy and comedian Josh Wolf.

15.03.2010 · 30 Min.

90210's Shenae Grimes is here to give us the deets on all things West Beverly. Comedian Bobby Lee, comedian T.J. Miller and comedian Whitney Cummings.

16.03.2010 · 30 Min.

From the highly anticipated Diary of a Wimpy Kid, the purely entertaining Rachael Harris is here. Comedian Jo Koy, comedian Loni Love and comedian Josh Wolf.

17.03.2010 · 30 Min.

We catch up with Avril Lavigne, who sings "Alice," the title song from Tim Burton's Alice in Wonderland. Comedian Sarah Colonna, comedian/TV host Rove McManus and comedian Mo Mandel.

18.03.2010 · 30 Min.

We're so thrilled to welcome the author of Where Mercy Is Shown, Mercy Is Given, Dog the Bounty Hunter. Comedian John Caparulo, comedian Heather McDonald and TV personality Ross Mathews.

22.03.2010 · 30 Min.

23.03.2010 · 30 Min.

24.03.2010 · 30 Min.

25.03.2010 · 30 Min.

29.03.2010 · 30 Min.

Ludacris is back with his new album Battle of the Sexes and this time he's bringing drinks. Comedian Ben Gleib, comedian Natasha Leggero and comedian Guy Branum.

30.03.2010 · 30 Min.

Johnny Weir is here, and unfortunately our show is not "on ice" this week. Comedian Jo Koy, comedian Lil JJ and comedian Sarah Colonna.